ISAT（InternationalSubarachnoidAneurysmTrial）随机试验：例破裂颅内动脉瘤患者神经外科手术夹闭与血管内弹簧圈栓塞的比较
InternationalSubarachnoidAneurysmTrial(ISAT)ofneurosurgicalclippingversusendovascularcoilinginpatientswithrupturedintracranialaneurysms:arandomisedtrial
背景尽管两种方法的相对获益尚未确定，血管内可解脱弹簧圈栓塞治疗仍然越来越多地被用作一些破裂颅内动脉瘤开颅夹闭手术的替代手段。我们开展了一项多中心随机试验，比较血管内弹簧圈栓塞与标准神经外科手术夹闭治疗适用于两种治疗方法动脉瘤的安全性和有效性。
BackgroundEndovasculardetachablecoiltreatmentisbeingincreasinglyusedasanalternativetocraniotomyandclippingforsomerupturedintracranialaneurysms,althoughtherelativebenefitsofthesetwoapproacheshaveyettobeestablished.Weundertookarandomised,multicentretrialto